Those RB matchups are pretty brutal. I'd go with Hillis but even he has some issues with Selvin Young looking ready to return and steal carries. The other two guys won't have any room to run IMO.
Still, with those WR options, I'd also go with Jones-Drew who has a nose for the endzone.
Steve Smith is too good to sit, and I'd go with Isaac Bruce as the last option.
You have some brutal matchups.